Description
Recombinant full-length human CK2a1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_001895.
CK2alpha is a serine-threonine protein kinase whose targets include many critical regulators of cellular growth. It is highly expressed in a lymphopro-liferative disease of cattle and in many human cancers. Overexpression of the CK2 catalytic subunit in lymphocytes of transgenic mice leads to T cell lymphoma (1). The highest CK2alpha1 activity is found in mouse testicles and brain, followed by spleen, liver, lung, kidney and heart (2)