Description
Recombinant full-length human CK1alpha1L was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is BC028723.
CK1alpha1L or casein kinase 1, alpha 1 like is a novel member of the CKI gene family which highlights a critical role for p53 in invasiveness control (1). CK1-alpha dynamically associates with the CBM complex on T cell receptor engagement to participate in cytokine production and lymphocyte proliferation which has a contrasting role by subsequently promoting the phosphorylation and inactivation of CARMA1 and it governs antigen-receptor-induced NF-kappa-B activation and human lymphoma cell survival (2)