Description
Interleukin-33 (IL-33) has an important role in allergic inflammation. It is a tissue-derived nuclear cytokine from the IL-1 family. IL-33 is abundantly expressed in endothelial cells, epithelial cells and fibroblast-like cells and acts as an alarm signal (alarmin) released upon cell injury or tissue damage to alert immune cells expressing the ST2 receptor (IL-1RL1)