Description
Recombinant human TNNI3K (300-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is BC117262.
The Cardiac Troponin I -interacting kinase (TNNI3K) is a serine/threonine-protein kinase, that is a member of the MAPKKK family (1). As a cardiac-specific kinase, it contains Ankyrin repeat, protein kinase, and serine-rich domains and highly expressed in the cardiomyocytes (1). Overexpression of TNNI3K has been shown to increase the progression of cardiomyopathy in mice through the Tyr and Ser/Thr kinase activity (2). The TNNI3K mutation has been involved in a familial syndrome of conduction system disease and dilated cardiomyopathy by causing the aggregation of this protein (3)