Description
Full-length recombinant mouse CDK20 (CCRK) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. This gene accession number is NM_053180.
CDK20 or cyclin-dependent kinase 20 contains a kinase domain most closely related to the cyclin-dependent protein kinases which may activate cyclin-dependent kinase 2 and is involved in cell growth. CDK20 is a monomeric CAK that specifically phosphorylates CDK2 thr160 and functions as a CDK2-activating kinase. CDK20 is also a novel cyclin-dependent kinase-activating kinase in mammalian cells (1). CDK20 depletion inhibits glioblastoma cell proliferation in a cilium-dependent manner (2)