Description
Recombinant human PINK1 (114-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number for PINK1 is BC028215.
PTEN-induced kinase 1 (PINK1) is a serine/threonine protein kinase that was identified initially in cancer cells as a gene up-regulated by overexpression of the major tumor suppressor, PTEN. It localizes to mitochondria, and regulates multiple aspects of mitochondrial biology. It is implicated in ubiquitin-dependent protein catabolic process to clear damaged mitochondria through selective autophagy (mitophagy). Mutations in the PINK1 gene are linked to early-onset recessive Parkinson disease