Description
Recombinant Human interleukin-11
Interleukin-11 (IL-11), also known as AGIF belongs to the IL-6 family of cytokines, and plays a protective role in acute inflammatory settings (Traber et al. 2019). IL-11 has both pro- and anti-inflammatory functions through activation of signaling cascades (Lokau et al. 2017). IL-11 is largely absent in the body fluids of healthy people, but is upregulated in a series of diseases. IL-11 can be expressed in fibroblasts, and its inhibition has been suggested as a treatment for fibrotic disease (Schafer et al. 2017), including fibrotic cardiovascular diseases (Ye et al. 2019). A role of IL-11 has also been identified in development of inflammation-associated cancers, and its inhibition may be a therapeutic goal (Putoczki et al. 2013).
This recombinant Human interleukin-11 can be used to create a standard curve in a sandwich ELISA with purified Mouse anti Human interleukin-11 antibody, clone D08-4C12 as a capture antibody and biotinylated Mouse anti Human interleukin-11 antibody, clone C16-4B8 as the detection antibody