Description
Shp-2 is one of two human Src Homology-2 (SH2) containing phosphatases, enzymes in which two regulatory phosphotyrosine binding domains (N-SH2 & C-SH2) lie N-terminal to the catalytic (PTP) domain. In most cases, full activation of the Erk/MAP kinase pathway by receptor tyrosine kinase signaling requires Shp-2, which is thought to act somewhere upstream of Ras