Description
CD6, also known as T-cell differentiation antigen CD6, is a member of the group B SRCR (scavenger receptor cysteine-rich) superfamily. CD6 is a cell surface glycoprotein expressed primarily on T cells and It expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. And T-cell differentiation antigen CD6 appears to play a role as both a co-stimulatory molecule in T cell activation and as an adhesion receptor. CD6 binds to CD166(known as ALCAM), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. Certain alleles of this protein may be associated with susceptibility to multiple sclerosis. Recombinant human CD6, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques