Description
Recombinant 2019-nCoV Spike protein S1 subunit, RBD (R346K, E484K, N501Y) was expressed in CHO cells using a C-terminal his tag. The gene accession number is MN908947.
The B.1.621 variant emerged from the parental B.1 lineage and was first found in Colombia in January 2021. The World Health Organization (WHO) designated the B.1.621 variant as Mu and classified it as a variant of interest (VOI) in August 2021 (1). The Mu variant (lineage: B.1.621) carries the mutations R346K, E484K, and N501Y on its RBD and the mutations manifest resistance to antiviral immunity. Compared to Delta, the Mu variant shows enhanced immune resistance to antibodies, and the E484K mutation, an escape mutation, is considered to be the reason for reducing the neutralizing ability of antibodies (2). As more variants of the virus emerge, it is pivotal to study the transmissibility, virulence, and their possible tendency to escape antibody neutralization of the virus (3)