Description
Recombinant full-length human PKC eta was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_006255.
PKCeta is a member of the protein kinase C (PKC) family of serine-and threonine-specific protein kinases that can phosphorylate a wide variety of protein targets known to be involved in diverse cellular signaling pathways. PKCeta is predominantly expressed in squamous cell epithelia and induces terminal differentiation of keratinocytes. PKCeta that is endogenously expressed or overexpressed is found to associate with the cyclin E/cdk2/p21 complex in keratinocytes of mice and humans (1)