Description
TrkC, also known as NT-3 growth factor receptor, is part of the large family of receptor tyrosine kinases. TrkC is the high affinity catalytic receptor for the neurotrophin NT-3 (neurotrophin-3). As such, TrkC mediates the multiple effects of this neurotrophic factor, which includes neuronal differentiation and survival. Family of neurotrophin receptors including NTRK3 have been shown to induce a variety of pleiotorpic response in malignant cells, including enhanced tumor cell invasiveness and chemotoxis. Increased NTRK3 expression has been demonstrated in neuroblastoma, in medulloblastoma, and in neuroectodermal brain tumors. Recombinant mouse TrkC, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques