Description
MKP-3 is a member of a group of dual specificity phosphatases which negatively regulate MAP kinases, dephosphorylating both the phosphotyrosine and phosphothreonine in the pTXpY activation loop motif. Transcriptional suppression of MKP-3 expression has been implicated in the development of pancreatic cancer. MKP-3 is located in the nucleus where it may act to anchor Erk 1/2