Description
Recombinant 2019-nCoV Spike protein S1 subunit, RBD (L452Q, F490S)(319-541) was expressed in CHO cells using a C-terminal his tag. The gene accession number is MN908947.
The receptor binding domain (RBD) of SARS-CoV-2 spike glycoprotein can recognize the ACE2 receptor of the host and is an important determining factor of viral entry and neutralization (1). The Lambda variant (VUI-21JUN-01, lineage C.37) carries the mutations L452Q and F490S on its RBD and the mutations manifest resistance to antiviral immunity. In addition, the L452Q mutation further increases the viral infectivity of the virus (2). The Lambda variant was first reported in Peru in August 2020, and since then has spread to most South American countries. As more variants of the virus emerge, it is pivotal to study the transmissibility, virulence, and the possible tendency to escape antibody neutralization of the virus (3)