Description
Recombinant human PTPRC (604-end) was expressed in Sf9 insect cells using an N-terminal His tag. The gene accession number is NM_002838.
PTPRC (CD45) contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus belongs to receptor type PTP (1). This gene is specifically expressed in hematopoietic cells (2). PTPRC has been shown to be an essential regulator of T-and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling