Description
Paraoxonase-1 or PON1 is part of the paraoxonase group of proteins. PON1 is an enzyme, responsible to the toxic metabolites of a different of organophosphorus insecticides hydrolyzation. Furthermore, PON1 is a dominant anti-atherosclerotic part of HDL. The enzyme needs PPAR-gamma for activation, leading to synthesis and release of paraoxonase 1 from the liver tissue, resulting in atherosclerosis reduction. PON1 has many qualities for atheroprotective through inflammatory lipid peroxides metabolism. This enzyme can hydrolyze a large number of substrates, for example cyclic carbonates, lactones, nerve gases etc.
PON1 Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain (16-355 a. A) containing a total of 346 amino acids, having a molecular mass of 39.0kDa.PON1 is fused to a 6 amino acid His-tag at C-terminus,and is purified by proprietary chromatographic techniques