Description
Recombinant full-length human IRAK2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_001570.
Interleukin-1 receptor-associated kinase 2 (IRAK2) is important downstream signaling components of Toll-like receptors (TLRs)(1). IRAKs were first described as signal transducers for IL-1 and later have been implicated in signal transduction of other members of the Toll/IL-1 receptor family. The interleukin-1 receptor (IL-1R) signaling pathway leads to NF?B activation in mammals. To date, four mammalian IRAKs have been identified (IRAK-1, IRAK-2, IRAK-4, and IRAK-M)(2). It is believed that IRAK-2 could be an additional therapeutic target for inhibiting IL-1-induced inflammation