Description
Full-length recombinant human H11 (HSP22) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. This gene accession number is NM_014365.
H11 or heat shock 22kDa protein 8 belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of H11 is induced by estrogen in estrogen receptor-positive breast cancer cells, and H11 also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. H11 is involved in regulation of cell proliferation, apoptosis, and carcinogenesis (1). H11 also causes motor neuron-specific neurite degeneration (2)