Description
Introduction: Envelope glycoprotein GP120 (or gp120) is a glycoprotein exposed on the surface of the HIVenvelope. The 120 in its name comes from its molecular weight of 120. Gp120 is essential forvirus entry into cells as it plays a vital role in attachment to specific cell surface receptors. Thesereceptors are DC-SIGN, Heparan Sulfate Proteoglycan and a specific interaction with the CD4receptor, particularly on helper T-cells. Binding to CD4 induces the start of a cascade ofconformational changes in gp120 and gp41 that lead to the fusion of the viral with the host cellmembrane. Binding to CD4 is mainly electrostatic although there are van der Waals interactionsand hydrogen bonds.
Description: gp120 protein expressed and purified from 293 cell culture. 6xHis tagged HIV-1 gp120 (HXBc2)(Clade B) protein (amino acid 34-518)(GenBank Accession No. K03455)