Description
Dickkopf-related protein 1 (Dkk-1), which belongs to the dickkopf family, is a secreted protein with two cysteine rich domains and is involved in embryonic development and many human diseases. The regulation of Wnt signaling and Dkk1 inhibition has implications for bone formation and homeostatis. Dkk-1 can inhibit Wnt signaling by binding to its receptors LRP5/6 and kremen1/2 to form a complex, which can prevent Wnt from binding to LRP5/6. The predicted mouse Dkk1 protein is 272 amino acid residues with an N-terminal signal peptide. It shares 86% amino acid identity to human Dkk-1 protein