Description
Recombinant full-length human Catenin beta was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag. The gene accession number is NM_001904.
beta-catenins are cytoplasmic proteins that are ubiquitously expressed. These proteins associate with E-cadherin at cellular junctions (1). beta-catenin interacts with TCF and LEF transcription factors and is an essential member of the Wingless-Wnt signal transduction pathway. The adenomatous polyposis coli (APC) tumor-suppressor protein, together with Axin and GSK3beta, form a Wnt-regulated signaling complex that mediates phosphorylation-dependent degradation of beta-catenin by the proteasome. APC and Siah-1 mediate a novel beta-catenin degradation pathway linking p53 activation to cell cycle control. Activating mutations in the human beta-catenin gene have been found in human colon cancer and melanomas (2)