Description
An annexin A1-mimetic peptide; binds to HEK293 cells expressing human FPR1 or FPR2 (EC50s = 1.4 and 1.8 µM, respectively, in a radioligand binding assay); inhibits PMN rolling over TNF-α-stimulated HUVECs at 10 and 30 µM; inhibits LPS-induced production of PGE2 and NO in rat microglial cells at 10 and 100 µg/ml; decreases pulmonary edema in a rat model of ventilator-induced ischemia-reperfusion injury at 0.5 and 1 mg/kg