Description
Bcl-xL is a transmembrane protein located in the mitochondrial membranes of cells that are long-lived and postmitotic, such as adult brain cells. It plays a role in the signal transduction pathway of the FAS-Ligand. Bcl-xL is an anti-apoptotic protein which is a member of the Bcl-2 family which are able to form heterodimers, and this is an significant event in the regulation of apoptosis. It is involved in the survival of cancer cells. Bcl-xL is the leading monitor of apoptosis/active cell suicide. It has cell death repressor activity and therefore acts as a survival protein. The Mouse Bcl-xL shares 97 % and 99 % a.a. sequence identity with human and rat Bcl-xL, respectively