Description
Mouse IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation and can regulating immune system cells. It promotes the anti-tumor activity of CD8+ T cells and NK cells. IL-21 elicits its effect through binding IL-21R, which also contains the gamma chain found in other cytokine receptors such as IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. IL-21 shows having much relation with clinical illnesses, including cancer immunotherapy, viral infections and allergies