Description
A peptide agonist of the guanylate cyclase C receptor; stimulates cGMP production in T84 cells (EC50 = 170 nM); reduces increases in the number of neoplastic colon epithelial cells expressing Ki-67 induced by DSS in cancer-prone Apc+/Min-FCCC mice at 10 ppm in the diet; suppresses trinitrobenzenesulfonic acid-induced increases in abdominal contractions in a rat model of visceral hypersensitivity at 0.01 and 0.05 mg/kg