Description
A peptide fragment of prosaposin and GPR37L1 and GPR37 agonist; activates ERK signaling in HEK293T cells expressing GPR37L1 or GPR37 (EC50s = 5 and 7 nM, respectively); protects primary mouse astrocytes from hydrogen peroxide-induced cell death at 100 nM; reduces allodynia in a variety of rat peripheral pain models at 4 mg/kg and prevents formalin-induced paw allodynia at 1 mg/kg