Description
Product Characteristics: DNA encoding the S1 portion of the Spike protein of SARSCoV-2 fused to a poly-histidine and a SEKDEL tag at the Cterminus was recombinantly expressed in Nicotiana benthamiana plants.
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Target Information: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes