Description
A peptide fragment of ApoE and an α7 nAChR antagonist (IC50 = 720 nM); suppresses TNF-α and NO release in BV-2 microglia from 10-50 µM; reduces LPS-induced increases in brain levels of TNF-α and IL-6 in mice; decreases hippocampal neuronal degeneration and the latency to find the platform in the Morris water maze in a mouse model of closed head injury induced by surgical midline impact at 203 and 406 µg/kg; delays disease onset and reduces disease severity in a mouse model of EAE at 1 mg/kg