Description
A GLP-1R agonist (IC50 = 3.5 nM); radiolabeled exendin-4 amide localizes to the pancreas, kidneys, and bladder in a porcine model of streptozotocin-induced diabetes; improves motor performance in the rotarod test in an MPTP-induced mouse model of Parkinson’s disease at 10 nmol/kg; reduces MPTP-induced loss of dopaminergic neurons in the substantia nigra in the same model