Description
A synthetic acetylated and amidated hexapeptide consisting of amino acid residues 12-17 of SNAP-25; inhibits formation of the SNARE complex in vitro in a concentration-dependent manner; inhibits calcium-induced norepinephrine release in permeabilized chromaffin cells (IC50 = 110 µM); inhibits decreases in type I collagen levels and skin thickness, as well as increases in type III collagen levels, in skin in a mouse model of subacute aging induced by D-galactose when administered topically at 10% in an oil-and-water emulsion