Fig 1: CTGF and VEGF-A highly expressed in the late-term of NP cell degeneration. NP cells were treated by IL-1β (10 ng/ml) from 1 day to 7 days. (A-D) The mRNA expression level of CTGF, VEGF-A, collagen I, and aggrecan II was assayed by RT-PCR. The values are mean ± SD of three independent experiments. (*P<0.05, **P<0.01, ***P<0.001)
Fig 2: The upregulation of CTGF and VEGF-A accelerated the fibrotic progression of NP cells. NP cells were treated, as mentioned above. (A, D) IF staining of collagen I and II (magnification: 400×), and (B, E) quantification analysis. (C, F) The mRNA expression level of aggrecan and collagen III was assayed by RT-PCR. The values are mean ± SD of three independent experiments. (*P<0.05, **P<0.01, ***P<0.001)
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