Description
Trefoil factor 2 (TFF2), also known as spasmolytic protein 1 is a small secreted protein1 and a member of the trefoil family of peptides. It is a highly stable peptide which is abundantly expressed and secreted by mucous cells of the stomach and has a functions in gastric cytoprotection.2 TFF2 is also detected at high concentrations around sites of ulceration. It is protective against mucosal damaging agents and stimulates cell motility.1 TFF2 is also useful in the treatment of colitis.3