Description
Resistin is a cysteine-rich protein secreted by adipose tissue of mice and rats. In other mammals, at least primates, pigs and dogs, resistin is secreted by immune and epithelial cells. Resistin is also known as CEBPE regulated myeloid-specific secreted cysteine-rich protein precursor 1 (XCP1), found in inflammatory zone 3 (FIZZ3), or "adipocyte-specific secretory factor" (ADSF). The length of the resistin pre-peptide in human is 108 aminoacids (in the mouse and rat it's 114 aa). Among the proteins synthesized and released from adipose tissue (adiponectin, angiotensin, estradiol, IL-6 [disambiguation needed], leptin, PAI-1, TNF-α), resistin is a cytokine whose physiologic role has been the subject of much controversy regarding its involvement with obesity and type II diabetes mellitus (T2DM)