Description
Fibroblast growth factor receptor-1 alpha (FGFR1-alpha) is an isoform of FGFR1 which is a receptor tyrosine kinase. FGFR1-alpha is expressed in prostate luminal epithelial cells.1 FGFR1alpha signals are posteriorizing factors that control node regression and posterior embryonic development.2FGFR1-alpha is a splice variant of FGFR1 containing the first immunoglobulin-like domain, whereas FGFR1-beta lacks this domain.2 The presence or absence of this N-terminal domain influences the affinity of the receptor towards aFGF and heparin.3 FGFR1-alpha is expressed in prostate luminal epithelial cells, whereas FGFR1-beta is expressed in basal epithelial cells and smooth muscle cells