Description
Activated leukocyte cell adhesion molecule (ALCAM/CD166) is an 82 kDa transmembrane glycoprotein and a member of the immunoglobulin gene superfamily. It is also known as MEMD, SC-1/DM-GRASP and KG-CAM. It is linked with cell migration and development and with cancer progression (1). ALCAM is expressed on natural killer cells, thymocytes, platelets, B cells, T cells and monocytes after cell activation, as well as eosinophils, fibroblasts, endothelial cells, keratinocytes and neurons (2). It is a ligand for CD6 and NgCAM but also engages in homophilic interactions. ALCAM/CD6 interaction plays a role in T cell development and T cell regulation (3)