Human CD122 / IL2RB Protein (ECD, mFc Tag) 10696-H05H from Sino Biological, Inc.

Product Specs
ItemHuman CD122 / IL2RB Protein (ECD, mFc Tag)
CompanySino Biological, Inc.
Price $398.00Supplier Page View Company Product Page
Catalog Number10696-H05H
Molecular WeightThe recombinant human IL2RB consists of 447 amino acids and predicts a molecular mass of 51 kDa
Size100 µg
Source/Expression SystemHEK293 Cells
Conjugate/TagC-mouse IgG1-Fc
FormatLyophilized from sterile PBS, pH 7.4
NCBI Gene AliasesCD122, IL15RB, IMD63, P70-75
NCBI Full Gene Nameinterleukin 2 receptor subunit beta
SpeciesHuman
Molecule NameIL2RB
TypeRecombinant protein
Activity1. Measured by its ability to bind biotinylated IL2 basic (Cat:11848-HNAE-B) in a functional ELISA. 2. Measured by its ability to inhibit IL-15-dependent proliferation of MO7e human megakaryocytic leukemic cells in the presence of 2 ng/mL of recombinant human IL-15. (Routinely tested). 3.Loaded Recombinant Human IL-2 Protein (Cat. No. 11848-HNAE2) on AR2G Biosensor, can bind Recombinant Human IL-2R beta/CD122 Protein, mFc Tag (Cat. No. 10696-H05H) with an affinity constant of 0.367 µM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested). 4.Recombinant Human IL-2R beta/CD122 Protein, mFc Tag (Cat. No. 10696-H05H) captured on CM5 chip via anti-mouse antibodies surface can bind Recombinant Human IL-2 Protein (Cat. No. 11848-HNAE2) with an affinity constant of 0.460 µM as determined in an SPR assay (Biacore T200) (QC tested)
Purity> 95 % as determined by SDS-PAGE

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(1) IL-2K35C-moFA, a Long-Acting Engineered Cytokine with Decreased Interleukin 2 Receptor α Binding, Improved the Cellular Selectivity Profile and Antitumor Efficacy in a Mouse Tumor ModelCancersSeptember 28, 2022Wang X, Chen G, Nie L, Wu Z, Wang X, Pan C, Chen X, Zhao X, Zhu J, He Q, et al.Spectramax M5 (Molecular Devices, San Jose, CA, USA). To detect the binding of samples to IL-2Rβ, IL-2Rβ-mFc (10696-H05H, Sino Biological, Beijing, China) was coated at a concentration of 2 μg/mL at 4 °C overnight. IL-2WT,

Human CD122 / IL2RB Protein (ECD, mFc Tag)