HDAC2, His-tag Recombinant 50002 from BPS Bioscience, Inc.

Product Specs
ItemHDAC2, His-tag Recombinant
CompanyBPS Bioscience, Inc.
Price $475.00Supplier Page View Company Product Page
Catalog Number50002
Size50 µg
Conjugate/TagC-terminal His-tag
FormatAqueous buffer solution
Molecular Weight56 kDa
SpeciesHuman
Domain/Region/Terminusfull length
NCBI Full Gene Namehistone deacetylase 2
NCBI Gene AliasesKDAC2, HD2, YAF1, RPD3
TypeProtein
Source/Expression SystemSf9 cells
insect
ApplicationsUseful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling

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BPS Bioscience, Inc.

6405 Mira Mesa Blvd

Suite 100

San Diego, CA 92121

United States

Phone: 858-202-1401

Email: sales-team@bpsbioscience.com

Company Profile

Website: https://bpsbioscience.com/

(1) TNG260 is a Small-Molecule CoREST Inhibitor that Sensitizes STK11-Mutant Tumors to Anti-PD-1 ImmunotherapyCancer ResearchOctober 15, 2025Leanne G. Ahronian, Soumyadip Sahu, Minjie Zhang, Ayushi S. Patel, Ke Geng, Reshmee Bhattacharya, Gerald S. Falchook, Jonathan W. Goldman, Alexander I. Spira, Salman R. Punekar, et al.Supplementary Table S1. Biochemical assay for deacetylase activity Recombinant HDAC1 (#50051), HDAC2 (#50002), and HDAC3/NCor2 (#50003) enzymes were purchased from BPS Bioscience. Assay reagents for the detection

(2) Reversible histone deacetylase activity catalyzes lysine acylationNature Chemical BiologySeptember 1, 2025Takeshi Tsusaka, Mohd. Altaf Najar, Benjamin Schwarz, Eric Bohrnsen, Juan A. Oses-Prieto, Helena Neudorf, Christina Lee, Jonathan P. Little, Alma L. Burlingame, Catharine M. Bosio, et al.Motif (31505) was used for experiments shown in Supplementary Fig. 4 and rHDAC2 from BPS Bioscience (50002) was used for Fig. 2g-i and Extended Data Fig. 7e-g. We selected vendors on the basis of the availability

(3) Targeting neuroblastoma with hydroxamic acid based HDAC1 and HDAC2 inhibitors: Insights from in vitro and in vivo studiesInvestigational New DrugsJuly 10, 2025Padmini Pai, Yashaswini Reddy, Ipshita Das, Babu Santhi Venkidesh, Poonam Bhandari, Pallavi Rao, Srinivas Oruganti, Keshava Prasad, Manasa Gangadhar Shetty, Kapaettu Satyamoorthy, et al.Eagle Medium (DMEM) was acquired from Himedia. HDAC1 (Catalogue No. 50051) and HDAC2 (Catalogue No. 50002) were purchased from BPS Biosciences. Chemical structure Two novel hydroxamic acid derivatives (3A—N-hydroxy[2,2'-bipyridine]-6-carboxamide

(4) Design and synthesis of thiazole-based hydroxamate histone deacetylase inhibitors with potent antitumor efficacy by inducing apoptosis, pyroptosis and cell cycle arrestSci RepJuly 9, 2025Zhijian Li, Huiran Qiu, Wenxia Lu, Namin Duan, Shule Fan, Rui Zhou, Xiangzhi Li, Hua Zhang, Ning Liu, Feifei Yangexecuted by Shanghai ChemPartner Corporation. HDAC enzyme (HDAC1 Active motif 31504, HDAC2 BPS Bioscience 50002, HDAC6 BPS Bioscience 50006, HDAC8 Active motif 31566) solution was preincubated with varying concentrations

(5) Sorbate induces lysine sorbylation through noncanonical activities of class I HDACs to regulate the expression of inflammation genesSci AdvMay 30, 2025Yi-Cheng Sin, Breann Abernathy, Zuo-Fei Yuan, Jason L. Heier, Justin E. Gonzalez, Laurie L. Parker, Douglas G. Mashek, Yue Chen(hs.Ri.HDAC3.13.1) was from Integrated DNA Technologies (Coralville, IA). Recombinant HDAC1 (50051), HDAC2 (50002), and HDAC3/NCOR2 (50003) were from BPS Bioscience (San Diego, CA). Sorbic acid–13C2 (S676891) was from

(6) Class I histone deacetylases catalyze lysine lactylationbioRxivMarch 1, 2025Takeshi Tsusaka, Mohd. Altaf Najar, Isha Sharma, Mariola M. Marcinkiewicz, Claudia Veronica Da Silva Da Silva Crispim, Nathaniel W. Snyder, George M. Burslem, Emily L. Goldbergfrom Cayman: rHDAC1 (10009231), rHDAC2 (36419), rHDAC3/NCOR2 (10009232). rHDAC2 from BPS Bioscience (50002) was used for Fig. 1B. We selected vendors based on the availability of recombinant proteins from each

(7) UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressorsNatureFebruary 12, 2025Megan J. R. Yeo, Olivia Zhang, Xiaowen Xie, Eunju Nam, N. Connor Payne, Pallavi M. Gosavi, Hui Si Kwok, Irtiza Iram, Ceejay Lee, Jiaming Li, et al.calculation. HDAC1/2 activity assays Recombinant HDAC1 (BPS Bioscience 50051) or HDAC2 (BPS Bioscience 50002) were diluted to 6 nM (1.2×) into buffer containing 50 mM HEPES, pH 7.5, 100 mM KCl, 0.5 mg ml−1 BSA,

(8) Discovery of novel biphenyl compounds bearing hydroxamic acid moiety as the first PD-L1/class I HDACs dual inhibitorsJ Enzyme Inhib Med ChemFebruary 6, 2025Dandan Yuan, Yali Gao, Lin Xia, Han Liu, Xingye Wu, Xueyan Ding, Yudan Huang, Changchun Deng, Jin Li, Wenqi Dai, et al.(Perkin Elmer, Cat. No. 6007279) were used. Human recombinant HDAC1 (Cat. No. 50051), HDAC2 (Cat. No. 50002), HDAC3 (Cat. No. 50003) and HDAC8 (Cat. No. 50008) were purchased from BPS Biosciences. SAHA (Cat.

(9) Design, Synthesis, and Biological Evaluation of 2-Anilino-4-Triazolpyrimidine Derivatives as CDK4/HDACs InhibitorsDrug Design, Development and TherapyApril 11, 2022Suhua Wang, Siyuan Han, Weiyan Cheng, Ruoyang Miao, Shasha Li, Xin Tian, Quancheng Kandiluted to certain concentrations. Then, the HDAC1 enzymes (Active Motif, 31504), HDAC2 (BPS bioscience, 50002), HDAC5 (BPS bioscience, 50005), HDAC6 (BPS bioscience, 50006), HDAC8 (Active Motif, 31566), HDAC11

(10) Development of a Novel, Small-Molecule Brain-Penetrant Histone Deacetylase Inhibitor That Enhances Spatial Memory Formation in MiceJournal of Medicinal ChemistryFebruary 24, 2022Jawad B. Belayet, Sarah Beamish, Mizzanoor Rahaman, Samer Alanani, Rajdeep S. Virdi, David N. Frick, A. F. M. Towheedur Rahman, Joseph S. Ulicki, Sreya Biswas, Leggy A. Arnold, et al.Recombinant, purified HDACs were obtained from BPS Bioscience: HDAC1 (Catalogue #50051), HDAC2 (Catalogue #50002), HDAC3 (Catalogue #50051), HDAC6 (Catalogue #50046), and HDAC8 (Catalogue #50008). Each protein was

(11) Discovery of an NAD⁺ analogue with enhanced specificity for PARP1Chemical scienceFebruary 16, 2022Zhang XN, Lam AT, Cheng Q, Courouble VV, Strutzenberg TS, Li J, Wang Y, Pei H, Stiles BL, Louie SG, et al.a GST-tag and HDAC2 with a His6 tag were purchased from BPS Bioscience (catalog numbers: 80502 and 50002; San Diego, CA). Human HMGA2 with a His6 tag was purchased from Novus Biologicals (catalog number: NBP2-23122;

(12) Class I histone deacetylases (HDAC1–3) are histone lysine delactylasesScience AdvancesJanuary 21, 2022Carlos Moreno-Yruela et al.HDAC1 (full length, C-terminal His tag, cat. #50051), HDAC2 (full length, C-terminal His tag, cat. #50002), HDAC3/NCoR2 [full length, C-terminal His tag, with DAD domain of NCor2, N-terminal glutathione S-transferase

(13) High-throughput screening of histone deacetylases and determination of kinetic parameters using fluorogenic assaysSTAR ProtocolsMarch 4, 2021Carlos Moreno-Yruela, Christian A. OlsenFLAG-tag)",BPS Bioscience,Cat#50051 HDAC2 (full length with C-terminal His-tag),BPS Bioscience,Cat#50002 HDAC3/NcoR2 (full length with C-terminal His-tag),BPS Bioscience,Cat#50003 "HDAC4 (aa 627–1,084 with

(14) Hydroxamic acid-modified peptide microarrays for profiling isozyme-selective interactions and inhibition of histone deacetylasesNature communicationsJanuary 4, 2021Moreno-Yruela C, Bæk M, Vrsanova AE, Schulte C, Maric HM, Olsen CA.≥ 79%, activity ≥ 460 pmol/min/µg), HDAC2 (full length, C-terminal His tag, BPS Bioscience, cat. #: 50002, lots 160701 and 160630, purity ≥ 84%, activity ≥ 675 pmol/min/µg), HDAC3/NCoR2 (full length, C-terminal

(15) Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 InhibitorsChemMedChemJuly 3, 2020Michael Morgen et al.System (G6421, Promega) with recombinant human HDACs (BPS Bioscience; HDAC1 cat. #50051; HDAC2 cat. #50002; HDAC3/NcoR2 complex cat. #50003; HDAC6 cat. #50006; HDAC8 cat. #50008). The assay was carried out in

(16) Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is ImplicatedJournal of medicinal chemistryMay 9, 2019Géraldy M, Morgen M, Sehr P, Steimbach RR, Moi D, Ridinger J, Oehme I, Witt O, Malz M, Nogueira MS, et al.tested using the HDAC‐Glo™ I/II Assay and Screening System (G6421, Promega) with recombinant HDAC2 (50002, BPS Bioscience). The assay was carried out in a 384‐well plate (4512, Corning) format using 10 ng/mL

(17) Divergent JNK Phosphorylation of HDAC3 in Triple-Negative Breast Cancer Cells Determines HDAC Inhibitor Binding and SelectivityCell chemical biologyNovember 16, 2017Hanigan TW, Aboukhatwa SM, Taha TY, Frasor J, Petukhov PA.Peptides, and Recombinant Proteins" HDAC1,BPS Bioscience,50051 Lot 150528-A HDAC2,BPS Bioscience,50002 Lot 130823-G HDAC3,BPS Bioscience,50003 Lot 130819 HDAC8,"Petukhov Laboratory, University of Illinois

(18) A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer’s Disease MiceNeuropsychopharmacologyJanuary 1, 2017Mar Cuadrado-Tejedor et al.Accession No. NM_001527), full length, with C-terminal His-tag was obtained from BPS Biosciences (Cat. no. 50002). Human HDAC3 (GenBank Accession No. NM_003883), full length, with C-terminal His-tag and human NCOR2,

(19) Discovery of a Novel HDAC2 Inhibitor by a Scaffold-Merging Hybrid QueryCombinatorial Chemistry & High Throughput ScreeningSeptember 3, 2015Nikita Basant, Xionghao Lin, Terry-Elinor Reid, Pradeep K Karla, Xiang S Wanginhibitor (1000, 631, 398, 251, 158, and 100 μM), 5 μL HDAC2 (1.8 ng/μL, BPS Bioscience, Catalog No. 50002), and 5 μL HDAC substrate (200 μM, BPS Bioscience, Catalog No. 50037). Prior to adding substrate, the

(20) Novel analogs targeting histone deacetylase suppress aggressive thyroid cancer cell growth and induce re-differentiationCancer gene therapyAugust 1, 2015Jang S, Yu XM, Odorico S, Clark M, Jaskula-Sztul R, Schienebeck CM, Kupcho KR, Harrison AD, Winston-McPherson GN, Tang W, et al.GraphPad Prism 6 (GraphPad Software, La Jolla, CA). BC, Canada). Human recombinant C-ter-HIS-HDAC 2 (50002) and N-ter-GSTHDAC 6 (50006) were purchased from BPS Bioscience (San Diego, CA). Human recombinant HDAC

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HDAC2, His-tag Recombinant

HDAC2, His-tag

HDAC2, His-tag Recombinant

HDAC2, His-tag Recombinant

HDAC2, His-tag Recombinant

HDAC2, His-tag Recombinant from BPS Bioscience, Inc.

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BPS Bioscience, Inc.

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HDAC2, His-tag Recombinant from BPS Bioscience, Inc.

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