AR-42 (OSU-HDAC42) 27603-2 from BPS Bioscience, Inc.

Description

AR-42 (also known as OSU-HDAC42), a derivative of hydroxamate-tethered phenylbutyrate is a broad-spectrum deacetylase inhibitor of both histone and non-histone proteins. AR-42 treatment induces histone hyperacetylation and p21WAF/CIP1 overexpression, inhibits gp130/Stat3 pathway and induces apoptosis and cell cycle arrest in multiple myeloma cells

Product Specs
ItemAR-42 (OSU-HDAC42)
CompanyBPS Bioscience, Inc.
Price $310.00Supplier Page View Company Product Page
Catalog Number27603-2
Size10 mg
ActivityAR-42 is a pan-HDAC inhibitor with IC50 of 16-30 nM. It has demonstrated greater potency and activity in solid tumors and hematological malignancies (including chronic lymphocyte leukemia, or CLL, B-cell lymphoma, prostate and ovarian cancers) when compared to vorinostat (SAHA), the first of two marketed compound in the class
Purity≥99% by HPLC
Molecular Weight312.4 Da
FormulaC₁₈H₂₀N₂O₃
TypeDeacetylase Inhibitor
TargetHDAC