Betulinic acid 27739-3 from BPS Bioscience, Inc.

Description

Betulinic acid is a natural pentacyclic triterpenoid that selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic acid also displays TGR5 agonist activity (EC50 =1.04 µM). Betulinic acid is used to study its potential cardiovascular role in the modulation of endothelium-dependent relaxation. Betulinic acid displays anti-HIV and antitumor activity

Product Specs
ItemBetulinic acid
CompanyBPS Bioscience, Inc.
Price $300.00Supplier Page View Company Product Page
Catalog Number27739-3
Size500 mg
ActivityInitially reported as a selective inhibitor of human melanoma, betulinic acid was found active against neuroectodermal (neuroblastoma, medulloblastoma, Ewing's sarcoma) and malignant brain tumors, ovarian carcinoma, in human leukemia HL-60 cells, and malignant head and neck squamous cell carcinoma SCC25 and SCC9 cell lines. In contrast, epithelial tumors, such as breast, colon, small cell lung and renal cell carcinomas, as well as T-cell leukemia cells, were completely unresponsive to treatment with betulinic acid
Molecular Weight456.7 Da
FormulaC₃₀H₄₈O₃
TypeActivator/Inducer