Description
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bindto certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-relatedcell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential forboth host specificity and viral infectivity. The spike (S) glycoprotein of coronaviruses is known to beessential in the binding of the virus to the host cell at the advent of the infection process