Description
Platelet-Derived Growth Factor (PDGF) is a member of the protein family which includes vascular endothelial growth factors (VEGF), important regulators of cell growth, proliferation, and angiogenesis. PDGF is proteolytically processed from a pre/pro protein to generate PDGF subunit B, which can homodimerize, or can heterodimerize with the related PDGF subunit A. The PDGF dimer binds the cell surface receptor tyrosine kinases PDGFR-α and PDGFR-β