SARS-CoV-2 (2019-nCoV) Spike RBD-His Recombinant Protein 40592-V08H from Sino Biological, Inc.

Product Specs
ItemSARS-CoV-2 (2019-nCoV) Spike RBD-His Recombinant Protein
CompanySino Biological, Inc.
Price $448.00Supplier Page View Company Product Page
Catalog Number40592-V08H
ActivityMeasured by its binding ability in a functional ELISA. Immobilized human ACE2 protein (Fc tag)(Cat: 10108-H05H) at 2 µg/mL (100 µL/well) can bind SARS-CoV-2/2019-nCoV Spike Protein (RBD, His Tag)(Cat: 40592-V08H), the EC50 of SARS-CoV-2/2019-nCoV Spike Protein (RBD, His Tag)(Cat: 40592-V08H) is 20-60 ng/mL
Conjugate/TagC-His
FormatLyophilized from sterile PBS, PH 7.4
Purity> 95 % as determined by SDS-PAGE
Molecular WeightThe recombinant SARS-CoV-2 (2019-nCoV) Spike Protein (RBD, His Tag) consists of 234 amino acids and predicts a molecular mass of 26.54 kDa
SpeciesSARS-CoV-2
Molecule NameSpike
Source/Expression SystemHEK293 Cells
TypeRecombinant protein
Size100 µg

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) Re-infection with SARS-CoV-2 is associated with increased antibody breadth and potency against diverse sarbecovirus strainsmBioApril 8, 2026Michelle Lilly, Felicitas Ruiz, William B. Foreman, Vrasha Chohan, Jamie Guenthoer, Delphine Depierreux, Viren A. Baharani, Duncan Ralph, Alex Harteloo, Helen Y. Chu, et al.VRC01. All described antibodies were tested for binding to SARS-CoV-2 WH-1 RBD (Sino Biological, cat. 40592-V08H), SARS-CoV-2 WH-1 S1 (Sino Biological, cat. 40591-V08H), SARS-CoV-2 XBB.1.5 trimer (40589-V08H45), and

(2) Determinants of natural killer cell-mediated antibody dependent cellular cytotoxicity in SARS-CoV-2 antibodiesPLoS PathogMarch 12, 2026Delphine M. Depierreux, Felicitas Ruiz, Michelle Lilly, Jamie Guenthoer, Vrasha Chohan, Julie Overbaugh40590-V08H1), SARS-CoV-2 NTD subunit (Sino Biologicals, 40591-V49H) and SARS-CoV-2 RBD (Sino Biological, cat. 40592-V08H). S2 epitope groups were assigned using a competition ELISA approach as described previously [45]. Data

(3) A pH-driven receptor switch from ACE2 to NPC1 enables endosomal entry of SARS-CoV-2ResearchSquareMarch 4, 2026Yong-Hui Zheng, Zhongshun Liu, Yu Pang, Ilyas Khan, Li Ou, Yixiang Hu, Sunan Li, Justin Richner, Tongqing ZhouElectron Microscopy Science. Recombinant proteins Recombinant SARS-CoV-2 RBD with a His-tag (Cat. No. 40592-V08H) and NPC1-C with His & Flag-tags (Cat. No. 16499-H32H) were purchased from SinoBiologicals. Recombinant

(4) Inducible CD147 up-regulation boosts extended SARS-CoV-2 infection triggering severe COVID-19 independent of ACE2Signal Transduct Target TherFebruary 3, 2026Ke Wang, Peng Lin, Ruo Chen, Qiang Huang, Yizhen Zhao, Lei Zhang, Yongxiang Zhao, Liping Zhong, Ke Xu, Linlin Bao, et al.and Vero E6-ACE2-KO) were cultured in 24-well plates at 37 °C overnight. His-RBD protein (500 ng/mL, 40592-V08H, Sino Biological) and 6×His-tag (500 ng/mL, QYAOBIO) were added in the medium for 24 h. Then, the cell

(5) Intranasal S-2P and lentinan formulation confers broad protection against SARS-CoV-2 VOCs via IFN-γ-dominant mechanismsnpj VaccinesJanuary 30, 2026Zhendong Pan, Xu Zheng, Liangliang Jiang, Cuiling Ding, Yangang Liu, Haoran Peng, Yan Liu, Yanhua He, Wanda Tang, Congcong Zhang, et al.baculovirus-insect cells (Sino Biological, 40589-V08B1), the RBD protein expressed in HEK293 cells (Sino Biological, 40592-V08H), the S1 protein expressed in 293 cells (Sino Biological, 40591-V08H), the S2 protein expressed in HEK293 cells

(6) Affinity maturation and light-chain-mediated paratope diversification anticipates viral evolutionCell ReportsJanuary 27, 2026John Dingus, Duck-Kyun Yoo, Sachin Kumar, Yajuan Wang, Md Golam Kibria, Shahab Saghaei, Zahra Allahyari, Jessica W. Chen, Natalie M. Caputo, Jason Hwang, et al.Tag),GenScript,Cat# Z03480 SARS-CoV-2 S (His & FLAG Tag),GenScript,Cat# Z03481 SARS-CoV-2 RBD,Sino Biological,Cat# 40592-V08H SARS-CoV-2 S2,Sino Biological,Cat# 40590-V08B SARS-CoV-2 NTD,Sino Biological,Cat# 40591-V49H Bovine

(7) High-affinity optimization potential of the virus neutralizing antibody with twin cysteine-stabilized complementarity-determining region 3Frontiers in Cellular and Infection MicrobiologyJanuary 14, 2026Jing Li, Dan-Dan Zeng, Qi Yin, Sen Zhang, Dong-Sheng Zhao, Yue Zhang, Zhang Zhang, Fan Tong, Zhong-Peng Zhao, Tao Jiang, et al.immobilized onto Anti-HIgG Fc probes biosensors. Secondly, the SARS-CoV-2 spike RBD protein (Sino Biological, 40592-V08H) was prepared as twofold serial dilutions (20, 10, 5, 2.5, 1.25, 0.625, and 0.3125 μg/mL) with Q-Buffer

(8) Elevated SARS-CoV-2 IgG4 in plasma and mucosa following repeated mRNA boosters impact antibody functions to Omicron and sarbecoviruseseBioMedicineJanuary 1, 2026Kevin J. Selva, Wen Shi Lee, Alther L. Enriquez, L. Carissa Aurelia, Jennifer Audsley, Helen E. Kent, Emily M. Eriksson, Nicholas Kiernan-Walker, J. Judy Chang, Janine M. Trevillyan, et al.custom SARS-CoV-2 bead array was designed using SARS-CoV-2 S Trimer and RBD (ancestral: #40589-V08H4, #40592-V08H; BA.1: #40589-V08H26, #40592-V08H121; XBB.1.5: #40589-V08H45, #40592-V08H146; JN.1: #40589-V08H59, #40592-V08H155;

(9) De novo design of epitope-specific antibodies via a structure-driven computational workflowNature CommunicationsDecember 10, 2025Fandi Wu, Yu Zhao, JiaXiang Wu, Biaobin Jiang, Bing He, Longkai Huang, Chenchen Qin, Yang Xiao, Fan Yang, Rubo Wang, et al.interaction interface to block viral attachment and prevent host cell infection. (Sino Biological, REF:40592-V08H). De novo designed phage display library construction The oligonucleotides encoding the designed antibodies

(10) Discovery of a pan anti-SARS-CoV-2 monoclonal antibody with highly efficient infected cell killing capacity for novel immunotherapeutic approachesEmerging microbes & infectionsDecember 1, 2025Abba Moussa D, Vazquez M, Chable-Bessia C, Roux-Portalez V, Tamagnini E, Pedotti M, Simonelli L, Ngo G, Souchard M, Lyonnais S, et al.Tris-NTA-Biotin (Biotechrabbit #BR1001201) followed by his-tagged Wuhan Spike RBD (Sino Biological # 40592-V08H). The library (1012 cfu) was depleted twice using Streptavidin-coated plates, before the first round.

(11) Pediatric T cell and B cell responses to SARS-CoV-2 infectionJCI insightOctober 22, 2025Hills LB, Bhat N, Hurst JH, Myers A, Burke TW, McClain MT, Petzold E, Rotta AT, Turner NA, Grifoni A, et al.40589-V08B1), S1 (Sino Biological, 40591-V08H), S2 (Sino Biological, 40590-V08B), RBD (Sino Biological, 40592-V08H), NTD (Sino Biological, 40591-V49H), NC (Sino Biological, 40588-V08B), and M (MyBiosource, MBS8574735)

(12) Safety and pharmacokinetics of SARS-CoV-2 DNA-encoded monoclonal antibodies in healthy adults: a phase 1 trialNature MedicineOctober 21, 2025Pablo Tebas, Ami Patel, Joseph T. Agnes, Elizabeth M. Parzych, Amanda Baer, Maria Caturla, Sukanya Ghosh, Mansi Purwar, Nicole Bedanova, Chungdhak Tsang, et al.plates were coated overnight at 4 °C with 1 µg ml−1 SARS-CoV-2 RBD proteins from ancestral (cat. no. 40592-V08H, Sino Biological), BA.4/5 (cat. no. 40592-V08H130, Sino Biological) and JN.1 (cat. no. 40592-V08H155,

(13) Differential modulation of SARS-CoV-2 infection by complement factor H and properdinFront ImmunolAugust 15, 2025Uday Kishore, Praveen M. Varghese, Chandan Kumar, Susan Idicula-Thomas, Martin Mayora Neto, Anthony G. Tsolaki, Pretty Ponnachan, Khaled Masmoudi, Basel Al-Ramadi, Manu Vatish, et al.recombinant SARS-CoV-2 S protein (RP-87680, Invitrogen) or recombinant SARS-CoV-2 spike RBD protein (40592-V08H, Sino-Biological). To investigate the binding of the FH or FP to the immobilised SARS-CoV-2 S or RDB,

(14) Engineered Dual‐Function Antibody‐Like Proteins to Combat SARS‐CoV‐2‐Induced Immune Dysregulation and InflammationAdvanced ScienceJuly 6, 2025Yizhuo Wang, Chenwu Bai, Kerui Hou, Zhen Zhang, Ming Guo, Xin Wang, Fan Yang, Xin Liu(https://www.uniprot.org/). ELISA The SARS‐CoV‐2 receptor‐binding domain (RBD) and spike protein were obtained from Sino Biological (40592‐V08H, 40589‐V08B1). Binding activities of ALPs to SARS‐CoV‐2 spike protein were assessed via ELISA. spike

(15) Endemic coronavirus infection is associated with SARS-CoV-2 Fc receptor-binding antibodiesJournal of virologyJune 17, 2025Bean DJ, Liang YM, Avila F, He X, Asundi A, Sagar M.titers were detected by ELISA as previously described (28). SARS-CoV-2 RBD protein (SinoBiological, 40592-V08H), SARS-CoV-2 S2 protein (SinoBiological, 40590-V08H1), SARS-CoV-2 nucleocapsid protein (SinoBiological,

(16) Systems serology-based comparison of humoral immune responses induced by liposome or aluminum hydroxide adjuvanted SARS-CoV-2 spike proteinSci RepMay 28, 2025Soo Ji Kim, Taewoo Kim, Satyanarayana Bejjani, Mi Sun Kim, Jung Hyuk Lee, Yuna Shin, Sun-Je Woo, Beom Min Cheon, Doyoung Kim, Sumin Lee, et al.40591-V08H), SARS-CoV-2 S2 protein (Sino Biological, 40590-V08H), and SARS-CoV-2 RBD protein (Sino Biological, 40592-V08H) were biotinylated (Thermo, A39257) after 2 h of incubation on ice for the multiplex antibody subclass

(17) Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunityCell reports. MedicineApril 15, 2025Tursi NJ, Tiwari S, Bedanova N, Kannan T, Parzych E, Okba N, Liaw K, Sárközy A, Livingston C, Trullen MI, et al.except for coating with the following proteins where indicated: SARS-CoV-2 wild type spike RBD (Cat# 40592-V08H, Sino Biologicals), SARS-CoV-2 D614G spike (Cat# 40589-V08H8, Sino Biologicals), SARS-CoV-2 B.1.617.2

(18) Sustained exposure to multivalent antigen-decorated nanoparticles generates broad anti-coronavirus responsesMatterApril 2, 2025Julie Baillet, John H. Klich, Ben S. Ou, Emily L. Meany, Jerry Yan, Theodora U. J. Bruun, Ashley Utz, Carolyn K. Jons, Sebastien Lecommandoux, Eric A. Appelantigens were purchased from Sino Biological: SARS-CoV-2 Spike RBD-His Recombinant Protein (cat. Number 40592-V08H-1), SARS-CoV-2 Spike protein (cat. Number 40591-V08H4), SARS-CoV-2 BA.4/BA.5/BA.5.2 Spike RBD-His Recombinant

(19) Dose-dependent serological profiling of AdCLD-CoV19-1 vaccine in adultsmSphereJanuary 28, 2025Jung Hyuk Lee, Yuna Shin, Kwang-Soo Shin, Ju Yeon Park, Mi Sun Kim, Young-Shin Park, Wuhyun Kim, Joon Young Song, Ji Yun Noh, Hee Jin Cheong, et al.Sino Biological), S1 (#40591-V08H, Sino Biological), S2 (#40590-V08H1, Sino Biological), and RBD (#40592-V08H, Sino Biological), as well as three Omicron BA.2 variant antigens, which included FS protein (#SPN-C522b,

(20) Evolution of SARS-CoV-2 spike trimers towards optimized heparan sulfate cross-linking and inter-chain mobilityScientific ReportsDecember 31, 2024Jurij Froese, Marco Mandalari, Monica Civera, Stefano Elli, Isabel Pagani, Elisa Vicenzi, Itzel Garcia-Monge, Daniele Di Iorio, Saskia Frank, Antonella Bisio, et al.S1-RBDs were used in this study: RBD of the first ermerged variant (Wuhan or 2019 nCoV, Sinobiological 40592-V08H), of the B.1.167.2 variant (Delta, Sinobiological 40592-V08H90), and of the B.1.1.529 variant (Omicron,

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SARS-CoV-2 (2019-nCoV) Spike RBD-His Recombinant Protein

SARS-CoV-2 (2019-nCoV) Spike RBD-His Recombinant Protein from Sino Biological, Inc.

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Sino Biological, Inc.

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SARS-CoV-2 (2019-nCoV) Spike RBD-His Recombinant Protein from Sino Biological, Inc.

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