SARS-CoV-2 (2019-nCoV) Spike S1-mFc Recombinant Protein 40591-V05H1 from Sino Biological, Inc.

Product Specs
ItemSARS-CoV-2 (2019-nCoV) Spike S1-mFc Recombinant Protein
CompanySino Biological, Inc.
Price $498.00Supplier Page View Company Product Page
Catalog Number40591-V05H1
Molecule NameSpike
SpeciesSARS-CoV-2
FormatLyophilized from sterile PBS, pH 7.4
Source/Expression SystemHEK293 Cells
Molecular WeightThe recombinant SARS-CoV-2 (2019-nCoV) Spike Protein (S1 Subunit, mFc Tag) consists of 904 amino acids and predicts a molecular mass of 101.4 kDa
Conjugate/TagC-mouse IgG1-Fc
Purity> 90 % as determined by SDS-PAGE
TypeRecombinant protein
ActivityMeasured by its binding ability in a functional ELISA. Immobilized human ACE2 protein (His tag) at 2µg/mL (100µL/well) can bind SARS-CoV-2 (2019-nCoV) Spike Protein (S1, mFc Tag)(40591-V05H1), the EC50 of 2019-nCoV Spike Protein (S1, mFc Tag) is 90-240 ng/mL
Size100 µg

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) The LDL receptor-related protein 1 (LRP1) facilitates ACE2-mediated endocytosis of SARS-CoV2 spike protein-containing pseudovirionsThe Journal of biological chemistryJune 1, 2025Wani MM, Cooper JM, Migliorini M, Strickland DK.

(2) Combinatorial Approach with Mass Spectrometry and Lectin Microarray Dissected Site-Specific Glycostem and Glycoleaf Features of the Virion-Derived Spike Protein of Ancestral and γ Variant SARS-CoV-2 StrainsJournal of proteome researchApril 5, 2024Hiono T, Sakaue H, Tomioka A, Kaji H, Sasaki M, Orba Y, Sawa H, Kuno A.

(3) Broad Epitope Coverage of Therapeutic Multi-Antibody Combinations Targeting SARS-CoV-2 Boosts In Vivo Protection and Neutralization Potency to Corner an Immune-Evading VirusBiomedicinesMarch 13, 2024Roodink I, van Erp M, Li A, Potter S, van Duijnhoven SMJ, Smits M, Kuipers AJ, Kazemier B, Berkeveld B, van Geffen E, et al.S1-S2-His, were purchased from Sino Biological (Beijing, China, cat.#’s 40591-V41H, 40591-V08H, 40591-V02H, 40591-V05H1, 40590-V02H, and 40589-V08B1, respectively). Spike protein trimers reflecting B.1.1.7, B.1.351, B.1.429,

(4) Assembly of Immunogenic Protein Particles toward Advanced Synthetic VaccinesSmall (Weinheim an der Bergstrasse, Germany)February 1, 2023Chen S, Quan DH, Sam G, Ozberk V, Wang XT, Halfmann P, Pandey M, Good MF, Kawaoka Y, Britton WJ, et al.

(5) Point-of-Care Diagnostic Biosensors to Monitor Anti-SARS-CoV-2 Neutralizing IgG/sIgA Antibodies and Antioxidant Activity in SalivaBiosensors (Basel)January 20, 2023Eiichi Tamiya, Shuto Osaki, Tomoko Tsuchihashi, Hiromi Ushijima, Keiichi Tsukinokipurchased from BBI Solutions (Cardiff, UK). Three different recombinants—the S1-mFc recombinant protein (40591-V05H1, Sino Biological, Beijing, China), the S1 + S2 recombinant with His-tag (BSV-CoV-PR-40, BioServ, San

(6) Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse ModelHuman Vaccines & ImmunotherapeuticsDecember 31, 2022Sheng Jiang et al.described. Briefly, 96-well plates were, respectively, coated with 0.5μg/ml of pre-S1 (Sino biological, 40591-V05H1), 0.5 μg/ml of pre-S2 (Sino biological, 40590-V08B), and 0.17 μg/ml of RBD (Sino biological, 40592-V08B)

(7) Mutational escape prevention by combination of four neutralizing antibodies that target RBD conserved regions and stem helixVirologica SinicaDecember 1, 2022Tang H, Ke Y, Liao Y, Bian Y, Yuan Y, Wang Z, Yang L, Ma H, Sun T, Zhang B, et al.week. The transfection efficiency was examined by flow cytometry using S1-mFc recombinant protein (Cat# 40591-V05H1, Sino Biological, Beijing, China) as primary antibody and FITC-AffiniPure Goat Anti-Mouse IgG (Cat#

(8) Analysis of Serologic Cross-Reactivity Between Common Human Coronaviruses and SARS-CoV-2 Using Coronavirus Antigen MicroarraybioRxivSeptember 16, 2022Saahir Khan et al.,Sino Biological,N-(AA)-Fc-C,40591-V02H Coronavirus,2019-nCoV,2019-nCoV,S1,,HEK293,Sino Biological,N-(AA)-Fc-C,40591-V05H1 Coronavirus,2019-nCoV,2019-nCoV,S2,,Insect Cells,Sino Biological,N-(AA)-His-C,40590-V08B Coronavirus,2019-nCoV,2019-nCoV,S1+S2,,Insect

(9) Prevalence of saliva immunoglobulin A antibodies reactive with severe acute respiratory syndrome coronavirus 2 among Japanese people unexposed to the virusMicrobiology and immunologyAugust 1, 2022Tsukinoki K, Yamamoto T, Saito J, Sakaguchi W, Iguchi K, Inoue Y, Ishii S, Sato C, Yokoyama M, Shiraishi Y, et al.mostly consisting of sIgA antibodies, and also serum IgA antibodies, spike‐1‐mFc recombinant protein (#40591‐V05H1; Sino Biological) was used as the virus antigen. However, as this recombinant protein was found to nonspecifically

(10) Ambient Temperature Stable, Scalable COVID‐19 Polymer Particle Vaccines Induce Protective ImmunityAdvanced Healthcare MaterialsFebruary 1, 2022Shuxiong Chen et al.SARS‐CoV‐2 Antigens ELISAs were performed using a recombinant purified SARS‐CoV‐2 S1 (Sino Biological; 40591‐V05H1) or N (Sino Biological; 40588‐V08) as antigens. ELISA plates were coated overnight at 4 °C with 50 µL

(11) SARS-CoV-2 reactive and neutralizing antibodies discovered by single-cell sequencing of plasma cells and mammalian displayCell reportsJanuary 18, 2022Ehling RA, Weber CR, Mason DM, Friedensohn S, Wagner B, Bieberich F, Kapetanovic E, Vazquez-Lombardi R, Di Roberto RB, Hong KL, et al.were then selected for antigen binding by incubating with SARS-CoV-2 S1-mFc 1:75 (Sinobiological, Cat: 40591-V05H1), S2-mFc 1:75 (Sinobiological, Cat: 40,590-V05B) on ice for 20 min, followed by a single wash and a

(12) SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19Bioscience reportsAugust 27, 2021Grobbelaar LM, Venter C, Vlok M, Ngoepe M, Laubscher GJ, Lourens PJ, Steenkamp J, Kell DB, Pretorius E.Spike protein S1 Subunit, mFcTag, was purchased from Sino Biological (Beijing, China) (catalog number 40591-V05H1) and prepared using double distilled water, following the instructions provided. A total of 400 µl diluent

(13) Full-Length Recombinant hSP-D Binds and Inhibits SARS-CoV-2BiomoleculesJuly 28, 2021Arroyo R, Grant SN, Colombo M, Salvioni L, Corsi F, Truffi M, Ottolina D, Hurst B, Salzberg M, Prosperi D, et al.human ACE2 protein were expressed in HEK293 cells and purchased from SinoBiologicals (#40591-V08H, #40591-V05H1, #10108-H05H, #40591-V08H3, #40591-V08H10), AcroBiosystems (#S1N-C52H3, #S1N-C52Hk, #S1N-C52Hg, #S1N-C52Hn,

(14) SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2ImmunityJune 8, 2021Lu Q, Liu J, Zhao S, Gomez Castro MF, Laurent-Rolle M, Dong J, Ran X, Damani-Yokota P, Tang H, Karakousi T, et al.hFc-tagged",KACTUS Biosystems,Cat#: COV-VM5S1 "SARS-CoV-2 spike S1, mFc-tagged",Sino Biological,Cat#: 40591-V05H1 "SARS-CoV-2 spike S1, mFc-tagged",Acrobiosystems,Cat#: S1N-C5257-100ug "SARS-CoV-2 spike RBD, hFc-tagged",KACTUS

(15) Multiplexed, quantitative serological profiling of COVID-19 from blood by a point-of-care testScience advancesJune 1, 2021Heggestad JT, Kinnamon DS, Olson LB, Liu J, Kelly G, Wall SA, Oshabaheebwa S, Quinn Z, Fontes CM, Joh DY, et al.using a Scienion S11 sciFLEXARRAYER (Scienion AG) inkjet printer: spike S1 (Sino Biological, catalog #40591-V05H1), spike RBD (Sino Biological, catalog #40592-V02H), and nucleocapsid protein (Leinco, catalog #S854).

(16) A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomesNature communicationsMay 11, 2021Guo Y, Huang L, Zhang G, Yao Y, Zhou H, Shen S, Shen B, Li B, Li X, Zhang Q, et al.#40592-V05H) or full-length S-his (Sino Biological, Catalog #40589-V08B1) or S1-mFc (Sino Biological, Catalog #40591-V05H1) or S1-his (Kactus, Catalog #COV-VM4S1). The next day the plate was washed four times with washing buffer

(17) Detection of cross-reactive immunoglobulin A against the severe acute respiratory syndrome-coronavirus-2 spike 1 subunit in salivaPloS oneJanuary 1, 2021Tsukinoki K, Yamamoto T, Handa K, Iwamiya M, Saruta J, Ino S, Sakurai T.wells were washed five times with wash solution. The antigen was spike 1-mFc recombinant protein (#40591-V05H1; Sino Biological, Beijing, China) comprising the SARS-CoV-2 spike 1 subunit with the spike protein receptor-binding

(18) Multiplexed, quantitative serological profiling of COVID-19 from a drop of blood by a point-of-care testmedRxiv : the preprint server for health sciencesNovember 7, 2020Heggestad JT, Kinnamon DS, Olson LB, Liu J, Kelly G, Wall SA, Fontes CM, Joh DY, Hucknall AM, Pieper C, et al.spots using a Scienion S11 sciFLEXARRAYER (Scienion AG) inkjet printer: Spike S1 (Sino Biological, cat# 40591-V05H1), Spike RBD (Sino Biological, cat# 40592-V02H), and Nucleocapsid protein (Leinco, cat# S854). Each protein

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SARS-CoV-2 (2019-nCoV) Spike S1-mFc Recombinant Protein

SARS-CoV-2 (2019-nCoV) Spike S1-mFc Recombinant Protein from Sino Biological, Inc.

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Sino Biological, Inc.

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SARS-CoV-2 (2019-nCoV) Spike S1-mFc Recombinant Protein from Sino Biological, Inc.

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