SARS-CoV-2 (2019-nCoV) Spike S1-His Recombinant Protein (HPLC-verified) 40591-V08H from Sino Biological, Inc.

Product Specs
ItemSARS-CoV-2 (2019-nCoV) Spike S1-His Recombinant Protein (HPLC-verified)
CompanySino Biological, Inc.
Price $498.00Supplier Page View Company Product Page
Catalog Number40591-V08H
Molecule NameSpike
SpeciesSARS-CoV-2
FormatLyophilized from sterile PBS, pH 7.4
Source/Expression SystemHEK293 Cells
Molecular WeightThe recombinant SARS-CoV-2 (2019-nCoV) Spike Protein (S1 Subunit, His Tag) consists of 681 amino acids and predicts a molecular mass of 76.5 kDa
Conjugate/TagC-His
Purity> 90 % as determined by SDS-PAGE. > 95 % as determined by SEC-HPLC
TypeRecombinant protein
Activity1. Measured by its binding ability in a functional ELISA. Immobilized human ACE2 protein (Fc tag)(Cat: 10108-H05H) at 2 µg/mL (100 µL/well) can bind SARS-CoV-2/2019-nCoV Spike Protein (S1 Subunit, His tag) (40591-V08H), the EC50 of SARS-CoV-2/2019-nCoV Spike Protein (S1 Subunit, His tag) (Cat: 40591-V08H) is 200-600 ng/mL. 2. Loaded ACE2 Protein, Human, Recombinant (mFc Tag) (Cat. No. 10108-H05H) on AMC Biosensor, can bind SARS-CoV-2 (2019-nCoV) Spike S1-His Recombinant Protein (Cat. No. 40591-V08H) with an affinity constant of 47.7 nM as determined by Octet RED System
Size100 µg

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) Nano-granulated zoledronate sensitizes innate immune metabolism to enhance vaccine-induced and antitumor immunityCell Reports MedicineMay 19, 2026Meifang Chen, Xiaojia Jiao, Zhicheng Yan, Yueheng Wang, Jing Zhang, Qinghua Wu, Minghui Li, Shumin Fan, Yuan Wang, Wenbing Dai, et al.proteins" ,, Hemagglutinin/HA Protein,SinoBiological,Cat # 40938-V08H Spike S1-His Recombinant Protein,SinoBiological,Cat # 40591-V08H Human Papilloma Virus type 16 (HPV 16) L1 protein (VLP),SinoBiological,Cat # HPV16 GM-CSF,PeproTech,Cat

(2) Secretory full-length human prosaposin (PSAP) inhibits SARS-CoV-2 infection through facilitating the release of S1 subunit of spike proteinmBioMay 13, 2026Chongyang Zhang, Peiwen Ding, Xia Xiao, Bei Wang, He Huang, Qiao Zhang, Lili Ren, Zichun Xiang, Zhuo Zhou, Xiaobo Lei, et al.Sigma-Aldrich, and Pierce IP lysis buffer (87788) was purchased from Thermo Fisher Scientific. S1-His (40591-V08H), ACE2-mFc (10108-H05H), RBD-hFc (40592-V02H), GST (11213-HNAE) proteins were purchased from Sino Biological. SARS-CoV-2

(3) Re-infection with SARS-CoV-2 is associated with increased antibody breadth and potency against diverse sarbecovirus strainsmBioApril 8, 2026Michelle Lilly, Felicitas Ruiz, William B. Foreman, Vrasha Chohan, Jamie Guenthoer, Delphine Depierreux, Viren A. Baharani, Duncan Ralph, Alex Harteloo, Helen Y. Chu, et al.to SARS-CoV-2 WH-1 RBD (Sino Biological, cat. 40592-V08H), SARS-CoV-2 WH-1 S1 (Sino Biological, cat. 40591-V08H), SARS-CoV-2 XBB.1.5 trimer (40589-V08H45), and SARS-CoV-1 GD01 trimer (Acro Biosystems, cat. SPN-S52Ht).

(4) SARS-CoV-2 Seroprevalence of Surinamese Children and Determinants of Seropositivity in the CCREOH/MeKiTamara CohortChildren (Basel)March 31, 2026Delmaliz Barreto-Vázquez, Jeanine M. Buchanich, Ernesto T. A. Marques, Hannah H. Covert, Firoz Abdoel Wahid, Ashna D. Hindori-Mohangoo, Wilco C. W. R. Zijlmans, Arti Shankar, Maureen Y. Lichtveld(RayBiotech, cat# 230–30164–100, Peachtree Corners, GA, USA) or recombinant S1 (Sino Biological, cat# 40591-V08H, Houston, TX, USA) at 2 µg/mL in carbonate/bicarbonate buffer was used to coat 96-well plates and incubated

(5) Determinants of natural killer cell-mediated antibody dependent cellular cytotoxicity in SARS-CoV-2 antibodiesPLoS PathogMarch 12, 2026Delphine M. Depierreux, Felicitas Ruiz, Michelle Lilly, Jamie Guenthoer, Vrasha Chohan, Julie OverbaughS1 but not NTD or RBD. The proteins used included: SARS-CoV-2 S1 WH-1 strain (Sino Biological, cat. 40591-V08H), SARS-CoV-2 S2 (mammalian cell-derived, cat. 40590-V08H1), SARS-CoV-2 NTD subunit (Sino Biologicals,

(6) Intranasal S-2P and lentinan formulation confers broad protection against SARS-CoV-2 VOCs via IFN-γ-dominant mechanismsnpj VaccinesJanuary 30, 2026Zhendong Pan, Xu Zheng, Liangliang Jiang, Cuiling Ding, Yangang Liu, Haoran Peng, Yan Liu, Yanhua He, Wanda Tang, Congcong Zhang, et al.HEK293 cells (Sino Biological, 40592-V08H), the S1 protein expressed in 293 cells (Sino Biological, 40591-V08H), the S2 protein expressed in HEK293 cells (Sino Biological, 40590-V08H1) and the HA protein of the

(7) Strong and early immune responses against SARS-CoV-2 in mice and rhesus macaques after BNT162b3 vaccinationnpj VaccinesJanuary 13, 2026Annette B. Vogel, Bonny G. Lui, Kristin Tompkins, Isis Kanevsky, Alexander Muik, Stefanie A. Krumm, Alptekin Güler, Mohan S. Maddur, Kerstin C. Walzer, Sonja Witzel, et al.peptides Purified recombinant SARS-CoV-2 S1 (S1) containing a C-terminal His tag (Sino Biological, cat# 40591-V08H) and RBD containing a C-terminal human Fc tag (Sino Biological, cat# 40592-V02H) were used in enzyme-linked immunosorbent assays

(8) Systemic and mucosal immune signatures of protection against SARS-CoV-2 transmission in humansCell Rep MedDecember 16, 2025Amaya Rojo-Fernandez, Sadaf Aslam, Fahmida Alam, Alba Escalera, Vicente Villamandos, Beatriz Catón, Gregoria Megías, Angel Gonzalez, Luis Buzón-Martín, Juan Ayllon, et al.HCoV-229 used for this project were purchased from Sino Biological (Cat. #40589-V08H4, # 40592-V08H80, # 40591-V08H, # 40590-V08H1, # 40607-V08B, # 40607-V08H1, # 40607-V08B1 and # 40605-V08B). Proteins were stored at

(9) Pediatric T cell and B cell responses to SARS-CoV-2 infectionJCI insightOctober 22, 2025Hills LB, Bhat N, Hurst JH, Myers A, Burke TW, McClain MT, Petzold E, Rotta AT, Turner NA, Grifoni A, et al.binding to the following antigens: whole spike (Sino Biological, 40589-V08B1), S1 (Sino Biological, 40591-V08H), S2 (Sino Biological, 40590-V08B), RBD (Sino Biological, 40592-V08H), NTD (Sino Biological, 40591-V49H),

(10) SARS-CoV-2 Antibody Levels and Infections in Multiple Vaccinated Employees Over TimeJ Med VirolOctober 18, 2025Ingrid Sander, Sabine Kespohl, Alexandra Beine, Kerstin Belting, Jürgen Bünger, Simon Weidhaas, Ingolf Hosbach, Christian Eisenhawer, Jan Gleichenhagen, Philipp Göcke, et al.as those used for the original recombinant SARS‐CoV‐2 S1 protein (Sino Biological, Ashburn, Germany, 40591‐V08H), described in 2022 [6]. When the WHO reference standard 20/136, derived from pooled human plasma of

(11) Production of Clinical-Grade SARS-CoV-2 Spike Ferritin Nanoparticle Protein Immunogen by Transient TransfectionVaccines (Basel)October 9, 2025Agnes Hajduczki, William C. Chang, Rafael De La Barrera, James F. Wood, Wei-Hung Chen, Elizabeth J. Martinez, Jaime L. Jensen, Rajeshwer S. Sankhala, Clayton Smith, Alexander Anderson, et al.[33]. SpFN reference material was used as a standard. SARS-CoV-2 Spike S1-His Recombinant Protein, 40591-V08H (Sino Biological, Beijing, China), served as a positive control. PBS was used as a negative control.

(12) Lipid Nanoparticles Formulated with a Novel Cholesterol-Tailed Ionizable Lipid Markedly Increase mRNA Delivery Both in vitro and in vivoInternational Journal of NanomedicineJuly 28, 2025Ju Hyeong Jeon, Huabin Zhu, Jane Qin, Luyao Wang, Stephanie Mou, Laura Katherine Langston, Ramesh Marasini, Jianzhu Chen, Renhuan Xu, Shuna Li, et al.Cat#44-2404-21) were coated with 1µg/mL recombinant SARS-CoV-2 spike protein (Sino Biological Inc., Cat#40591-V08H) overnight and blocked with 2% BSA in PBS. Mouse sera collected on days 14 and 35 post-primary immunization

(13) Lipid Nanoparticles Formulated with a Novel Cholesterol-Tailed Ionizable Lipid Markedly Increase mRNA Delivery Both in vitro and in vivoInt J NanomedicineJuly 28, 2025Ju Hyeong Jeon, Huabin Zhu, Jane Qin, Luyao Wang, Stephanie Mou, Laura Katherine Langston, Ramesh Marasini, Jianzhu Chen, Renhuan Xu, Shuna Li, et al.Cat#44-2404-21) were coated with 1µg/mL recombinant SARS-CoV-2 spike protein (Sino Biological Inc., Cat#40591-V08H) overnight and blocked with 2% BSA in PBS. Mouse sera collected on days 14 and 35 post-primary immunization

(14) Fluorescence Polarization-Based High-Throughput Screening Assay for Inhibitors Targeting Cathepsin LBio ProtocJuly 20, 2025Keyu Guo, Baoqing You, Wenwen Zhou, Yan Li, Zhen Wang, Jing Zhang, Shuyi Si(Meilun Biotech, catalog number: MA0352-1) 4. SARS-CoV-2 S protein (Sino Biological, catalog number: 40591-V08H) 5. CTSL DNA fragment (NCBI reference sequence: NM_001912.4, synthesized by GenScript Biotech) 6. FP

(15) Fluorescence Polarization-Based High-Throughput Screening Assay for Inhibitors Targeting Cathepsin LBio ProtocJuly 20, 2025Keyu Guo, Baoqing You, Wenwen Zhou, Yan Li, Zhen Wang, Jing Zhang, Shuyi Si(Meilun Biotech, catalog number: MA0352-1) 4. SARS-CoV-2 S protein (Sino Biological, catalog number: 40591-V08H) 5. CTSL DNA fragment (NCBI reference sequence: NM_001912.4, synthesized by GenScript Biotech) 6. FP

(16) The quantity and quality of B-cell immunity against SARS-CoV-2 in children with cancer and hematological diseasesFront ImmunolJuly 2, 2025Eva Tiselius, Emil Sundberg, Amanda Ramilo Amor, Hanna Andersson, Renate Varnaite, Linda Kolstad, Dario Akaberi, Jiaxin Ling, Arja Harila, Shanie Saghafian-Hedengren, et al.anti-SARS-CoV-2 IgG and IgA (24). Briefly, recombinant wildtype SARS-CoV-2 S protein subunit 1 (S1) (#40591-V08H, Sino Biological, Beijing, China) was coupled to magnetic beads (MagPlex microspheres; Luminex Corp.,

(17) The pan-variant potential of light: 425 nm light inactivates SARS-CoV-2 variants of concern and non-cytotoxic doses reduce viral titers in human airway epithelial cellsmSphereJune 25, 2025Stasko N, Arwood L, Jandick N, Spragion D, Roberts RC, Setién M, Henson I, Annas A, Fulcher ML, Brotton M, et al.FBS in PBST) and incubated at 37°C/5% CO2 for 1 h. His-tagged recombinant WA1 S1 (Sino Biological #40591-V08H), Omicron B.1.1.529 S1 (Sino Biological #40591-V08H41), MERS-CoV S1 (Sino Biological #40069-V08H), SARS-CoV-1

(18) Systems serology-based comparison of humoral immune responses induced by liposome or aluminum hydroxide adjuvanted SARS-CoV-2 spike proteinSci RepMay 28, 2025Soo Ji Kim, Taewoo Kim, Satyanarayana Bejjani, Mi Sun Kim, Jung Hyuk Lee, Yuna Shin, Sun-Je Woo, Beom Min Cheon, Doyoung Kim, Sumin Lee, et al.functional assays. SARS-CoV-2 full S protein (Sino Biological, 40589-V08H4), SARS-CoV-2 S1 protein (Sino Biological, 40591-V08H), SARS-CoV-2 S2 protein (Sino Biological, 40590-V08H), and SARS-CoV-2 RBD protein (Sino Biological,

(19) BA.1 breakthrough infection elicits distinct antibody and memory B cell responses in vaccinated-only versus hybrid immunity individualsiScienceApril 18, 2025Carla Saade, Timothée Bruel, Lou-Léna Vrignaud, Martin Killian, Annabelle Drouillard, Véronique Barateau, Maxime Espi, Natacha Mariano, Charlotte Mignon, Lily Bruyère, et al.binding A custom SARS-CoV-2 multiplex assay was designed with the Wuhan Hu-1 S (Sino Biological, #40591-V08H) and N (Sino Biological, #40588-V08B) and the BA.1 S (Sino Biological, #40589-V08H30) antigens. Tetanus

(20) SARS-CoV-2 Spike S1 subunit triggers pericyte and microvascular dysfunction in human pancreatic isletsDiabetesMarch 1, 2025Catarina Andrade Andrade Barboza, Luciana Mateus Gonçalves, Elizabeth Pereira, Roxana Diaz Cruz, Ruy Andrade Louzada, Maria Boulina, Joana Almaçaroom temperature with 80 nmol/L recombinant SARS-CoV-2 (2019-nCoV strain) spike S1 subunit (cat. no. 40591-V08H; SinoBiologicals) or HCoV-OC43 spike S1 protein (cat. no. 40607-V08H1; SinoBiologicals). Slices were

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SARS-CoV-2 (2019-nCoV) Spike S1-His Recombinant Protein (HPLC-verified)

SARS-CoV-2 (2019-nCoV) Spike S1-His Recombinant Protein (HPLC-verified) from Sino Biological, Inc.

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Sino Biological, Inc.

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SARS-CoV-2 (2019-nCoV) Spike S1-His Recombinant Protein (HPLC-verified) from Sino Biological, Inc.

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