Description
CCL19 (also known as Macrophage Inflammatory Protein-3beta, MIP-3beta, and EBI1 ligand chemokine, ELC) directs chemotaxis of dendritic cells and certain B-and T-lymphocytes, but not monocytes or granulocytes. It is constitutively expressed in thymus and lymph nodes and binds specifically to target cells expressing the receptor CCR7. As a homeostatic chemokine, its primary physiological role is thought to be in the normal recirculation and homing of lymphocytes. However, CCL19 can also be proinflammatory and is implicated in post-HIV infection responses