Description
Description: Cyclophilin F Rat Recombinant produced in E Coli is asingle, non-glycosylated polypeptide chain containing 200 amino acids (30-206 a.a) and having a molecular mass of 21.2Da.
Cyclophilin F is fused to a23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction: PPIF is a part of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIF accelerates the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIF is key component of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death