Description
Description: The E.coli expressed recombinant HBV Pre-S is a single non-glycosylated polypeptide chain containing 174 amino acids and having a molecular weight of 20 kDa.
The C-terminal 6x his tagged recombinant Hepatitis B virus Pre-S is a single nonglycosylated polypeptide chain containing 174 amino acids and having a molecular weight of 20 kDa. (Genebank accession#: AGP08909).
Introduction: Hepatitis B virus surface gene encodes 3 proteins: small (HBs), middle (MHBs) and large (LHBs) surface protein. These 3 proteins are translated from distinct start codons, however share a common reading frame and stop codon. HBs contains 226 amino acids, it is a major viral envelope component. MHBs has extra 55 amino acids (Pre-S2) located to the N-terminus of HBs, LHBs has an additional 119 amino acids (Pre-S1). Pre-S is a region is comprised of Pre-S1 and S2, Pre-S1 has a vital role in receptor recognition, while Pre-S2 plays a part in translocation of virus into host cell. Clinically, HBV pre-S is linked with HBsAg and HBV DNA copies, which indicates active replication of virus, reduction of pre-S is typically associated with decreased HBV DNA copies, pointing to an improved predictor of treatment