Description
Description: IL4R produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (26-232 a.a.) and fused to an 8 aa His Tag at C-terminus containing a total of 215 amino acids and having a molecular mass of 24.7kDa. IL4R shows multiple bands between 28-40kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.
Introduction: Interleukin-21 receptor, also known as IL21R is a member of the type Icytokine receptors family. IL21R forms a heterodimeric receptor complex withthe common gamma-chain, a receptor subunit which is also shared by thereceptors for interleukin 2, 4, 7, 9, and 15. Furthermore, IL21 receptortransduces the growth promoting signal of IL21, and is significant for theproliferation as well as differentiation of T cells, B cells, and naturalkiller (NK) cells. The ligand binding of IL21 receptor leads to the activationof numerous downstream signaling molecules, including JAK1, JAK3, STAT1, aswell as STAT3