Description
Description: STIP1 Mouse Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 563 amino acids (1-543) andhaving a molecular mass of 64.7kDa. STIP1 is fused to a 20 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
Introduction: STIP1 is an adaptor protein that mediates the functions of HSP70 & HSP90 in protein folding. STIP1 supports the transfer of proteins from HSP70 to HSP90 by binding together HSP90 and substrate-bound HSP70. STIP1 stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones. STIP1 genetic variations are involved in regulating corticosteroid response in asthmatic subjects with reduced lung function