Description
Description: TGFBR2 Human Recombinant produced in in Sf9 Baculoviruscells is a single, non-glycosylated polypeptide chain containing 383 aminoacids (23-166a.a) and having a molecular mass of 43.3kDa (Migrates at 40-57kDaon SDS-PAGE under reducing conditions). TGFBR2 is expressed with a 239aa hIgG-His tag atC-Terminus and purified by proprietary chromatographic techniques.
Introduction: TGFBR2 is part of the Ser/Thr protein kinase family and the TGFB receptor subfamily. TGFBR2 is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. TGFBR2 expression is increased in oral squamous cell carcinoma cells. TGFBR2 attenuates the biological activities of TGF-beta in colorectal cancer. TGFBR2 expression is decreased by IL-1beta while inducing Sp3 via NFkappaB. TGFB2 and TGFBR2 are involved in the antiestrogenic activity of tamoxifen metabolites in breast cancer